Additional Street Closures Begin for Mayo Clinic’s Downtown Rochester Expansion

Rochester, MN (KROC-AM News)- More road closures to accommodate Mayo Clinic Expansion work in Rochester are underway. 

Read More: Overview of Rochester's 2026 Road Construction Projects

That’s according to Mayo Clinic’s construction website. 

The new round of closures impact two streets around Mayo’s campus in downtown Rochester, where a $5 billion expansion is taking place. 

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Road Closures Begin on 4th Ave. SW, 4th Ave. NW and 6th Ave. SW in Downtown Rochester

4th Ave. SW is now closed between West Center St. and 2nd St. SW. Mayo’s construction website says the permanent closure is to “support the connection between the two future clinical buildings.” 

The Rochester City Council voted in November of 2024 to vacate the two-block stretch of 4th Ave. SW to Mayo Clinic. 

Read More: Rochester City Council Votes to Pave the Way for Mayo Clinic Expansion 

Further north, 4th Ave. NW will be closed to through traffic between 2nd St. NW and West Center St.

Mayo says a temporary two-way traffic pattern will be in place to allow traffic to enter and exit the Graham Parking Ramp. 

A time table for that closure has not been given. 

6th Ave. SW Closure Expands

An additional block of 6th Ave. SW is now closed for construction. The closure of the street between 2nd St SW to 3rd St SW will accommodate utility work for the expansion. 

Officials say the work will be completed in phases and is scheduled to wrap up by next year. 6th Ave. SW has been closed between West Center St. and 2nd St. SW since last year. 

Mayo Clinic is encouraging motorists to follow posted detour signs.